LRRK2 and Parkinson disease: Point mutations at the p.R1441 hotspot (p.R1441C/G/H) in LRRK2 are pathogenic for Parkinson’s disease (PD) and have high penetrance (Haugarvoll et al., 2008; Klein and Westenberger, 2012; Domingo and Klein, 2018; Ruiz-Martínez et al., 2010).