ZNF638 and multiple sclerosis: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium (Harroud et al.)recently reported the association of a genetic variant with multiple sclerosis (MS) severity.1 This variant, rs10191329 (DYSF-ZNF638), was identified in a group of 12,584 European patients and replicated in an additional 9805 with either relapse-onset or primary progressive MS.