Serum ATG5 level was negatively correlated to MMSE score at enrollment (P=0.004) (Figure 3A), year 1 (P=0.002) (Figure 3B), year 2 (P=0.014) (Figure 3C), and year 3 (P=0.001) (Figure 3D) in stroke patients. The gene discussed is ATG5; the disease is Stroke.