Furthermore, immunofluorescence imaging revealed that combined treatment with anti‐IFNAR therapy alleviated the anti‐PD‐L1 inhibitor‐induced tumor vessel normalization (Fig. 5E,F), indicating the restoration of the anti‐PD‐L1 inhibitor‐induced alterations in TME by an anti‐IFNAR inhibitor. This evidence concerns the gene CD274 and neoplasm.