In addition, MO3.13 cells were subjected to oxygen and glucose deprivation (OGD) and treated with PD0325901 (PD, a MEK inhibitor), and changes in MEK, ERK, and myelin basic protein (MBP) expression in the cells after 4 days of treatment were assessed to explore the influence of exercise intervention on the myelin sheath after cerebral ischemia and the role of the MEK/ERK signaling pathway in this effect. This evidence concerns the gene MBP and brain ischemia.