It has been found that p53 can regulate ferroptosis of HCC cells through multiple pathways as follows (1): The expression of SLC7A11 is inhibited by transcription, the uptake of cystine is inhibited, the substrate of GSH is reduced, synthesis is insufficient, and the content of GSH is decreased, thus the activity of GPX4 in cells is inhibited, the antioxidant capacity in vivo is weakened, oxidation is dominant, and ferroptosis of HCC cells is promoted (47). The gene discussed is GPX4; the disease is hepatocellular carcinoma.