Previous experimental data suggests that multiple signaling pathways, such as hedgehog (HH), Fas/Fas Ligand (FasL), Notch, p53, and transforming growth factor beta 1 (TGF-β1)/Smad3, can either impede or facilitate the progression of liver fibrosis by influencing the behavior of HSCs [11,16]. The gene discussed is TGFB1; the disease is Hepatic fibrosis.