METTL3 (methyltransferase-like 3, writer), the most important m6A methylase, is abnormally activated in leukemia as studies have shown that overexpression of METTL3 can lead to enhanced proliferation and self-renewal abilities of leukemia stem cells and increase the m6A level in the promoter and enhancer regions, resulting in tumor development and progression [11], [12]. This evidence concerns the gene METTL3 and leukemia.