As the upregulated genes were mostly associated with virus infection pathways (Fig S3B), we focused on 13 genes with decreased m6A and expression levels (Fig. S5), among which three genes (i.e., HPRT1, SNRPC, and ANP32B) that were found to be significantly associated with the prognosis of AML patients were ultimately selected (Fig. 3 D-F). Here, HPRT1 is linked to viral infectious disease.