The in vivo importance of this CCL2/CCR2 axis was recently demonstrated in a K14-HPV8 E6 transgenic mouse model, in which cSCC occurs spontaneously at a rate of 6% and is strongly enhanced and accelerated by UV irradiation or skin wounding (Marcuzzi et al., 2009). The gene discussed is CCR2; the disease is skin squamous cell carcinoma.