CCL2 and dysplasia: Importantly, crossing K14-HPV8 E6 transgenic mice with mice lacking the chemokine receptor CCR2, which responds to the monocyte chemoattracting protein (MCP-1, CCL2), the key regulator of monocyte chemotaxis, prevented signs of epidermal hyperplasia and dysplasia after UV irradiation, suggesting a key role of monocyte recruitment in HPV8-associated skin carcinogenesis (Lelios et al., 2021).