CD4 and neoplasm: IHC experiments showed that MC38-sh-circNCOA3-derived tumors presented a high amount of CD8+, but not CD4+, tumor-infiltrating lymphocytes (TILs) [Figure 4A and B, Supplementary Figure 1] and reduced infiltration of myeloid-derived suppressor cells (MDSCs) [Figure 4C and D, Supplementary Figure 1].