showed that PFKFB3 expression was decreased in OA cartilage tissue as well as tumor necrosis factor (TNF)-α- or IL-1β-regulated chondrocytes, accompanied by decreased glucose utilization, ATP production, and lactate production, suggesting that PFKFB3 is impaired in OA and contributes to glycolysis disorders (70). The gene discussed is PFKFB3; the disease is glycolytic process.