Based on both Cox and Logistic regression models, this study scanned each biomarker’s potential association with T2D glycaemic deterioration then established causal relationships for some of these identified proteins, such as the Reticulon-4 receptor (NogoR/RTN4R) and the Interleukin-18 receptor 1 (IL18R1). Here, IL18R1 is linked to type 2 diabetes mellitus.