Based on both Cox and Logistic regression models, this study scanned each biomarker’s potential association with T2D glycaemic deterioration then established causal relationships for some of these identified proteins, such as the Reticulon-4 receptor (NogoR/RTN4R) and the Interleukin-18 receptor 1 (IL18R1). This evidence concerns the gene RTN4R and type 2 diabetes mellitus.