The TCM herbal monomer Danshinone IIA (Tan IIA) can alleviate kidney damage in db/db mice, possibly by inhibiting cell pyroptosis through the regulation of NLRP3 and thioredoxin-interacting protein (Txnip) expression, thus delaying the progression of diabetic kidney disease (DKD) (Wu et al., 2023a). The gene discussed is TXNIP; the disease is diabetic kidney disease.