GCG and Hypoglycemia: In elderly patients with diabetes, the secretion of incretin is reduced, the storage and release function of glycogen is weakened, the ability of self-regulating hypoglycemia is reduced, the liver and kidney functions are reduced, and multi-drug treatment caused by various chronic comorbidities (including heart disease, stroke, and chronic kidney disease) can increase the risk of severe hypoglycemia (Corsonello et al., 1999; Lipska et al., 2016).