As the inductions of caspase-3 mediated apoptotic pathway through the treatment of CAPE, IONP/CAPE, and RGD-IONP/CAPE were confirmed by the increased expression of caspase-3 and PARP-1, it is reasonably to hypothesize that the interactions between HS-5 bone marrow stromal cells and RPMI8226 MM cells provided a microenvironment to “buffer” the cytotoxicity from CAPE, IONP/CAPE and RGD-IONP/CAPE. Here, PARP1 is linked to Miyoshi myopathy.