IKZF1 and plasma cell myeloma: In addition to the induction of oxidative stress (Marin et al., 2019), this compound was reported to downregulate the expression of IRF-4, Sp-1, and the IKZF-1-IRF4-MYC axis, key factors for myeloma cell growth and survival, in MM cells (Murugesan et al., 2020).