The physiologic mechanisms for hypoglycemia development in those on exogenous insulin include the profound glucose-lowering effect of insulin, along with the probability of impaired glucose counterregulation caused by a blunting of several counterregulatory hormones including the catecholamines, cortisol, growth hormone and, in particular, glucagon (Verhulst et al., 2022). The gene discussed is GCG; the disease is Hypoglycemia.