Emerging evidence suggests that the blunting of glucagon secretion is related to elevations in SST secretion in sub-optimally controlled diabetes (Gaisano et al., 2012; Rorsman and Huising, 2018) and that the inhibition of SSTR2 can help restore the glucagon response to hypoglycemia, at least in animal models of T1D (Yue et al., 2012; 2013; Karimian et al., 2013). This evidence concerns the gene GCG and type 1 diabetes mellitus.