In one large trial evaluating the incidence of hypoglycemia using self-monitoring of blood glucose and/or interstitial continuous glucose monitors, it was found that −56% of T2D patients on insulin had hypoglycemic events, as defined as a glucose ≤60 mg/dL, over a 72-h observational period (Zick et al., 2007). The gene discussed is INS; the disease is Hypoglycemia.