However, it is currently unclear if the same physiologic dysregulation in SST signalling exists in T2D, but those with long-standing disease, appear to have a reduced or absent glucagon response to hypoglycemia, especially in those treated with insulin who tend to have recurrent episodes of iatrogenic hypoglycemia (Murayama et al., 1989; Dagogo-Jack et al., 1993; Cryer, 2012; Oyer, 2013). This evidence concerns the gene INS and type 2 diabetes mellitus.