BMP2 and precursor B-cell acute lymphoblastic leukemia: Therefore, in this study, high-throughput sequencing was used to analyze the whole transcriptome in peripheral blood mononuclear cells (PBMCs) of B-ALL, and the differentially expressed miR-539-5p and its target gene bone morphogenetic protein 2 (BMP2) were screened to be involved in Treg regulation in B-ALL.