Subsequently, 464 candidate PRGs were identified by subgroup analysis method and trained by Lasso-penalized Cox regression model (Fig. S1D, E), which winnowed the list down to seven genes: AEBP1, C20orf203, ENPP7P10, LPO, PTPRU, TMEM217, and UCA1. The expression of those seven genes was significantly different between AML patients from the TCGA-LAML cohort and normal controls from the GTEx cohort (Fig. S1F). Here, TMEM217 is linked to acute myeloid leukemia.