At the individual gene level, we identified several genetic alterations more prevalent in EO but not LO patients with HCC, including JAK1, BRCA1, and HDAC2 mutations, amplifications of MDM2, IL7R, and TERT, as well as deletions of EP300, CDH1, and PALB2 (Fig. 1B). This evidence concerns the gene MDM2 and hepatocellular carcinoma.