Several genetic biomarkers were found negatively associated with patient's OS in HCC, including high TMB (P < 0.001), EP300 deletion (P = 0.003), TP53 deletion (P = 0.02), IL7R amplification (p = 0.04), and Hippo pathway variants (P = 0.02; Table S4). Here, TP53 is linked to hepatocellular carcinoma.