Recently, Twist1 has been established to play pivotal roles not only in the development of various organs and systems but also in cancer metastasis (Yang et al., 2004; Kwok et al., 2005; Puisieux et al., 2006; Cheng et al., 2008a; Cheng et al., 2008b; Li et al., 2009; Fu et al., 2011). The gene discussed is TWIST1; the disease is cancer.