Overall, our results provide new insights into the enterotoxic activity of SEB during S. aureus infections, which may lead to the exacerbation of chronic inflammatory diseases such as IBD (103), especially following infections by MRSA (8, 9, 104), and the identification of a novel mimetic peptide able to attenuate inflammatory-dependent epithelial barrier dysfunctions. This evidence concerns the gene SETBP1 and infection.