STAT3 and trisomy: Combined immunodeficiencyi) with syndromic features e.g. Trisomy 21, immune osseous dysplasia, NBAS deficiency, Kabuki Syndromeii) without syndromic features (e.g. CARD-11 mutation)iii) 22q11 mutationiv) Hyper IgE syndrome (STAT3 loss of function)