Both SLE and SjS patients have demonstrated significant cell-specific epigenome-wide and genomic-wide hypomethylation of IFN-regulated genes in the epithelial cells from minor salivary gland as well as multiple tissues, with numerous sites being linked to augmented levels of IFN-regulated genes (13, 100, 103). This evidence concerns the gene IFNA1 and systemic lupus erythematosus.