↓ global DNA methylation levels in patients with SS. ↓ global methylation associated with lymphocyte infiltration in MiSG; ↓ global methylation associated with anti-La/SSB positive SS cases demethylation at SSB promoter caused higher levels of transcripts and SSB super expression in 5-Aza-C-treated HSG cells. The gene discussed is SSB; the disease is synovial sarcoma.