Hypomethylation in IFITM1, myxoma resistance1, PARP9, deltex E3 ubiquitin ligase 3L (DTX3L), and epithelial-stromal interaction 1 (EPSTI1), which eventually effect the IFN signaling in SjS monocytes, was testified. The gene discussed is DTX3L; the disease is Schwartz-Jampel syndrome.