Specifically, a heightened proliferation of CD8+T cells and a greater proportion of activated CD8+T cells expressing TCF1 (percentage of Tpex cells within the PD-1+CD8+T cell cohort) positively correlated with improved survival, especially when juxtaposed against the proportion of TCF1+CK cells in the overall tumor cell population. The gene discussed is CD8A; the disease is neoplasm.