These include the “don’t-eat-me” signaling molecules which inhibit macrophage phagocytosis of tumor cells, CD24 and CD47, the checkpoint molecules CD274 (PD-L1), PDCD1LG2 (PD-L2) and CD276, as well as the non-classical major histocompatibility complex I (MHC-I) molecule, HLA-G which inhibits NK cells (52, 53). This evidence concerns the gene CD276 and neoplasm.