In a pre-clinical animal study, the same group used a cartilage proteoglycan (PG, aggrecan)-derived peptide aggrecan89-103 as an autoantigenic epitope encapsulated into liposomes with or without calcitriol, and the liposomes were tested in the PG-induced arthritis (PGIA) model of RA. The gene discussed is ACAN; the disease is rheumatoid arthritis.