Accordingly, at sacrifice, 3 weeks after T-cell infusion, a higher proportion of TCRED-IRCOMP cells infiltrating the bone marrow co-expressed multiple IRs compared to TCRED-LAG-3KO cells (Supplementary Figure 7F), indicating that LAG-3 disruption in T cells redirected against NY-ESO-1 curtails the upregulation of other inhibitory receptors, even in stressed conditions of tumor outgrowth. The gene discussed is LAG3; the disease is neoplasm.