HAVCR2 and neoplasm: In these stressed conditions, TCRED-TIM-3KO and TCRED-2B4KO lymphocytes displayed a higher degranulation capacity than TCRED-IRCOMP counterparts, when challenged with U266 (Figure 4B) or MM1.s A2posESO-1pos cell lines (Figure 4C), indicating that the lack of TIM-3 and 2B4 in tumor-specific T cells sustains prolonged effector functions and overcomes exhaustion upon chronic antigen exposure.