MAPT and frontotemporal dementia: Notably, there is considerable complexity in the correspondence between these clinical syndromes and molecular pathologies in patients with FTD.2 In fact, while bvFTD is the most common clinical subtype of FTD characterized by changes in personality and social behaviours, emotion and insight,3 its neuropathological backgrounds include all FTLD-tau subcategories (i.e. PSP, CBD, Pick’s disease and argyrophilic grain dementia) and FTLD-TDP,4 precluding the estimation of disease-associated protein subspecies based on clinical profiles.