By taking advantage of 18F-florzolotau in the high-contrast detection of Alzheimer’s disease and non–Alzheimer’s disease tau assemblies with distinct isoform compositions,17 the regionality of tau pathologies in cases with FTD was classified into 3RT-like, 4RT-like, tau-negative and Alzheimer’s disease–like subcategories. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.