Among these radioligands, 11C-PBB3 was generated to capture a wide range of tau aggregates, including those in 3RT and 4RT pathologies of non-Alzheimer’s disease type.13  11C-PBB3 has enabled the visualization of tau depositions in patients with Alzheimer’s disease, PSP and traumatic brain injury,14-16 but it has only produced a relatively small dynamic range due to its high propensity for metabolic conversions. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.