Our clinical assessments showed that patients with bvFTD in this study had severe apathy, disinhibition, behavioural disturbances and diet- and sleep-related disturbances (Fig. 6), which were all generally in agreement with the known symptomatic features of this FTD subcategory.23 In addition, tau accumulations in the striatum were inversely correlated with cognitive abilities and frontal functions as assessed by MMSE and FAB, respectively (Fig. 5). Here, MAPT is linked to Apathy.