PICK1 and frontotemporal dementia: We observed multiple ROIs with Z-score > 1 in the frontal GM of this case following PVC (Fig. 4), yet the corrected SUVRs may not sufficiently reflect high loads of 3RTs confirmed as numerous Pick bodies in the post-mortem analysis.17 This discrepancy should not be an issue in an early diagnostic assessment of individuals with FTD in coordination with emerging anti-tau treatments, whereas the PVC methodology may need to be optimized for examining imaging–neuropathology correlations in the same individual with marked neuronal loss.