Three cases with CBS consisted of two Aβ-negative individuals with 4RT-like tau depositions (CBS1 and CBS2 in Fig. 2B) and one Aβ-positive individual with Alzheimer’s disease–type tau distribution (lower right images in Fig. 2A; CBS3 in Fig. 2B). The gene discussed is MSRB2; the disease is early-onset autosomal dominant Alzheimer disease.