As a unique cytokine, IL-32 can switch its roles between the proinflammatory and anti-inflammatory programs on many diseases as Crohn's disease, rheumatoid arthritis, chronic obstructive pulmonary disease, ulcerative colitis, psoriasis, atopic dermatitis, and tuberculosis and so on by producing the multiple isoforms through the alternative splicing [32–35]. The gene discussed is IL32; the disease is psoriasis.