As a unique cytokine, IL-32 can switch its roles between the proinflammatory and anti-inflammatory programs on many diseases as Crohn's disease, rheumatoid arthritis, chronic obstructive pulmonary disease, ulcerative colitis, psoriasis, atopic dermatitis, and tuberculosis and so on by producing the multiple isoforms through the alternative splicing [32–35]. This evidence concerns the gene IL32 and rheumatoid arthritis.