We have shown that there is an interaction between BMAL1 and RORα and they modulate HIF-1α activity as well as ECM homeostasis and perturbation in circadian clock genes results in disc degeneration (Suyama et al., 2016; Dudek et al., 2017; Wang et al., 2022; Dudek et al., 2023). Here, CLOCK is linked to intervertebral disk degenerative disorder.