Based on bioinformatic analysis, a series of experiments showed that the MYC/ERRα axis regulates mitochondrial respiration in osteoclastogenesis, and their targeting protected mice of oestrogen deficiency-mediated bone loss after ovariectomy, pointing to MYC as a potential therapeutic target for osteoporosis (Bae et al., 2017). Here, MYC is linked to osteoporosis.