CCNE2 and familial Mediterranean fever: The top upregulated gene was the cell-cycle protein CCNE2. A heatmap of the DEGs (Figure S2D) indicated that, while the two groups still clustered separately, there was a heterogeneous response to LPS in particularly the healthy control group that (also due to the relatively small sample size in this study) may have contributed to the masking of the true differential transcriptomic signature of monocytes in the FMF patients.