In the BRCA case network, we observed that the predicted cancer genes PIK3CA, SP1, and NCOA3 co-regulate the PTK2 AS (SE event) through intermediate SFs MAPK1 and NCOR1 (indicated by blue edges), which are enriched on multiple cancer-related pathways in KEGG, such as the "endocrine resistance" and "choline metabolism in cancer". The gene discussed is PIK3CA; the disease is cancer.