Our data revealed that eight-week HIIT could attenuate kidney damage in an animal model of T2D (T2D induced by high-fat diet and a single dose of STZ) by improving GFR, disrupted renal structures, reducing oxidative stress, decreasing pro-inflammatory and increasing anti-inflammatory markers, and reducing KIM-1 and Fetuin-A. The gene discussed is HAVCR1; the disease is type 2 diabetes mellitus.