Specifically, the authors showed that the fecal and ileal microbiomes of lupus prone toll-like receptor 7 (TLR7) transgenic mice were enriched with L. reuteri while cecal metastasis study and treatment with the immunomodulatory and antitumorigenic agent imiquimod, also revealed aggravation of systemic autoimmunity in gut microbiota [77]. The gene discussed is TLR7; the disease is systemic lupus erythematosus.