Finally, in the bacterial infection group, we measured OPG serum levels after recovery (15 days after diagnosis) and found a statistically significant decrease in OPG levels, (5.17 pmol/l (3.64–10.04) vs 3 (2.17–5.5)) (p < 0.005) (Fig. 3). Here, TNFRSF11B is linked to bacterial infectious disease.