Therefore, to further culture H1299 cells with HCC827 and M0 macrophages, we found that after over-expression of KCNE1, NPC2, SFTPD, M0 macrophage polarization significantly decreased (Fig. 12F), and the amount of tumor-promoting cytokines secreted by cells was significantly reduced (Fig. 12G). This evidence concerns the gene NPC2 and neoplasm.