In contrast, the meta-analysis revealed a significant association between SLE and the TLR7 rsrs3853839 GG + GA genotype in the overall population (OR = 3.479, 95% CI = 1.231–9.836, P = 0.038) as well as in Arab and Asian populations (OR = 2.135, 95% CI = 1.502–3.035, <0.001; OR = 23.20, 95% CI = 14.13–38.08, <0.001) (Table 2, Fig. 2B). Here, TLR7 is linked to systemic lupus erythematosus.