The CYP2A6 variants such as the rs5031016 which comprised the CYP2A6*7 allele with AF of 13.0% and rs28399468 which comprised of the CYP2A6*8, *10 alleles with AF 4.5% in the Vietnamese population were reported to be deleterious for the response of patients. This evidence concerns the gene CYP2A6 and atrial fibrillation.