To explore the status and function of CD8+ MAIT cells in COPD+ and COPD− NSCLC, we detected some important markers of CD8+ MAIT cells, including activation marker CD69, immune exhaustion marker PD1, cytotoxic markers GZMB and IFN‐γ, by flow cytometry (Figure 2A). This evidence concerns the gene GZMB and chronic obstructive pulmonary disease.