The AUC of TP53, EGFR, TGFB1, SOX2 and MAPK14 was found to be 0.7600, 0.7050, 0.6925, 0.7550, and 0.7450, respectively (Figs. 5F-J), which could be indicated to be of significant value in the diagnosis of osteoporosis. This evidence concerns the gene SOX2 and osteoporosis.