Encoding p53 transcription factor, TP53 is the most frequently mutated tumor suppressor gene in all human cancer types, as manifested by the evidence that p53 could inhibit the expression of cystine and SLC7A11, a key component of glutamate antiporter, while reducing cellular antioxidant capacity and exacerbating ferroptosis [32]. The gene discussed is SLC7A11; the disease is cancer.