These stroke-associated white matter microglia (SAWM) showed lower expressions of the homeostatic microglial markers (P2ry12, Tmem119, etc.)along with elevated expressions of the DAM- and/or MGnD-related genes (Apoe, Trem2, Ctsb, Ctsd, etc.)[17] (Fig. 2b). Here, TREM2 is linked to stroke disorder.