The results of this study showed that cultured MDMs obtained from SSc patients affected by ILD, seem to be significantly characterized by a stronger M2 phenotype at higher profibrotic activity (CD204, CD206 and CD163) compared to cultured MDMs from HSs and MDMs obtained from SSc patients without ILD, particularly for a significantly higher gene expression of TGFβ1 and MerTK. Here, TGFB1 is linked to systemic sclerosis.