HIF1A and obesity due to melanocortin 4 receptor deficiency: To confirm the effects of PDGFRβ + cell HIF1α inactivation on WAT remodeling and liver lipid accumulation in obesity, a new TAM-inducible Hif1a knockout system (Pdgfrb-CreERT2, Hif1aloxP/loxP; herein denoted as Hif1a-bKO mice) were generated (Fig. S2A).