Additionally, in an in vitro study of SK-N-SH human neuroblastoma cells, Aβ preferentially activates the PERK-eIF2α pathway, and silencing PERK leads to cell death, which is mitigated by Salubrinal, a selective activator of eIF2α(Bobrovnikova-Marjon et al. 2010). Here, EIF2AK3 is linked to neuroblastoma.