TBX21 and type 2 diabetes mellitus: Results indicated that the expression of GATA-3 (transcription factor of Th2) was significantly upregulated (p < 0.01) (Fig. 6C, E-F), while the expression of T-BET (transcription factor of Th1) was significantly downregulated in the 150 mg/ml ART-loaded TCH group when compared with the T2DM group (p < 0.05) (Fig. 6D-E).