Activating transcription factor 4 (ATF4) participates in heat shock protein family A member 5 (HSPA5) expression and upregulation of solute carrier family 7 member 11 (SLC7A11) to inhibit ferroptosis, thus enhancing the resistance of pancreatic cancer cells or glioma cells to ferroptosis caused by gemcitabine or dihydroartemisinin (Dixon et al. 2014). This evidence concerns the gene HSPA5 and central nervous system cancer.