On the other hand, transcription of the glutathione (GSH)-degrading enzyme chac glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1) mediated by ATF4 enhances the ferroptosis of breast cancer cells induced by artesunate or cystine starvation (Chen et al. 2017). The gene discussed is CHAC1; the disease is breast carcinoma.