The HIV-Tocky system captured the dynamics of the very early phase of HIV-1 infection, including the simultaneous productive infection and latent reservoir establishment as reported in vivo64, in a time-sensible manner in the primary CD4 + T cells, Jurkat T, and THP-1 myeloid cell lines (Fig. 1 c, g, and Supplementary Fig. 2). The gene discussed is CD4; the disease is HIV-1 infection.