In preclinical study, in neuroglioma and NSCLC knockdown of PCSK9 gene determinants cancer apoptosis using the caspase‐3 and XIAP/p‐Akt pathways and in melanoma-bearing mice PCSK9 gene silencing considerably boosts the response to immune checkpoint inhibitors (ICIs) [113, 114]. The gene discussed is AKT1; the disease is cancer.