Similar to DMFI in SCAN-B, when stratifying by ROR category in METABRIC, the highest expression of CAV1 (T3) conferred borderline increased risk of breast cancer-specific death adjusted HR 1.24 (95% CI 0.95–1.62) only in patients with tumors classified as ROR High but not in ROR Low/Intermediate tumors, Table 2, Fig. 2, Supplementary file 1: Supplementary Fig. 6 and 7. The gene discussed is CAV1; the disease is breast cancer.