Considering the interactions between ROR categories and CAV1 expression in SCAN-B, interaction analyses between ROR categories and CAV1 tertiles for all four endpoints were performed to investigate if potential effect modifications previously seen in SCAN-B was the underlying reason for the discrepant findings on prognosis in METABRIC. Here, CAV1 is linked to spinocerebellar ataxia, autosomal recessive, with axonal neuropathy.