We speculate that comorbid PTSD/AUD are mediated by CeA γ-aminobutyric acid (GABA)-ergic signaling because prior work identified an increase in CeA GABAergic signaling in stressed rats, possibly through CRF, FKBP5 (GR co-chaperone), and Nr3c1 (which encodes the GR) [31, 39, 62–64]. This evidence concerns the gene CRH and post-traumatic stress disorder.